A Common NURR1 Polymorphism Associated With Parkinson Disease and Diffuse Lewy Body Disease
نویسندگان
چکیده
منابع مشابه
A common NURR1 polymorphism associated with Parkinson disease and diffuse Lewy body disease.
BACKGROUND NURR1 plays a key role in mesencephalic dopaminergic neuron development and survival. A homozygous NURR1 polymorphism (a single base-pair insertion in intron 6) (NI6P) has been reported to be associated with Parkinson disease (PD). OBJECTIVE To assess the association of the NI6P with PD and diffuse Lewy body disease. DESIGN Case-control study. SETTING Movement disorders clinic ...
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Several components of Lewy bodies have been identified, but the precise mechanism responsible for the formation of Lewy bodies remains undetermined. The 14-3-3 protein family is involved in numerous signal transduction pathways and interacts with alpha-synuclein, which is a major constituent of Lewy bodies. To elucidate the role of 14-3-3 proteins in neuro-degenerative disorders associated with...
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Diffuse Lewy body disease (DLBD) has been studied from various viewpoints and, although clinical diagnostic criteria for DLBD have been proposed, diagnosis remains difficult. DLBD has been reported to be the second most common form of dementia in the aged, following Alzheimer-type dementia. It has, however, been clinically under-diagnosed. Therefore, the search for diagnostic markers for DLBD m...
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BACKGROUND The significance of Lewy bodies detected at autopsy in the brains of clinically normal individuals is uncertain but may represent preclinical Parkinson disease (PD). OBJECTIVE To determine whether diminished striatal dopaminergic innervation and nigral cell loss are present in incidental Lewy body disease (iLBD), as one might expect if it is a forerunner of PD. DESIGN Case-contro...
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ژورنال
عنوان ژورنال: Archives of Neurology
سال: 2003
ISSN: 0003-9942
DOI: 10.1001/archneur.60.5.722